Genomic fold assignment and rational modeling of proteins of biological interest.
Proc Int Conf Intell Syst Mol Biol
; 8: 296-306, 2000.
Article
en En
| MEDLINE
| ID: mdl-10977091
ABSTRACT
The first available genome of a multicellular organism, C. elegans, was used as a test case for protein fold assignment using PSI-BLAST, followed by rational structure modeling and interpretation of experimental mutagenesis data in the context of collaboration with biologists. Similar results are demonstrated for human disease proteins with known polymorphisms.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Proteínas
/
Modelos Moleculares
/
Genoma
/
Pliegue de Proteína
/
Caenorhabditis elegans
Límite:
Animals
/
Humans
Idioma:
En
Año:
2000
Tipo del documento:
Article