Stereocontrolled synthesis of a sphingomyelin methylene analogue as a sphingomyelinase inhibitor.
Org Lett
; 2(17): 2627-9, 2000 Aug 24.
Article
en En
| MEDLINE
| ID: mdl-10990413
ABSTRACT
[reaction see text]Efficient synthesis of a sphingomyelin methylene analogue, which was designed as a sphingomyelinase inhibitor, was stereoselectively achieved. The Hofmann rearrangement of the alpha-hydroxyethyl-beta-hydroxy amide 4 followed by the intramolecular oxazolidinone ring formation was one of the key steps.
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Banco de datos:
MEDLINE
Asunto principal:
Esfingomielina Fosfodiesterasa
/
Esfingomielinas
/
Inhibidores Enzimáticos
Idioma:
En
Año:
2000
Tipo del documento:
Article