The cell biology of ion pumps: sorting and regulation.
Eur J Cell Biol
; 79(8): 557-63, 2000 Aug.
Article
en En
| MEDLINE
| ID: mdl-11001492
ABSTRACT
The physiologic function of an ion pump is determined, in part, by its subcellular localization and by the cellular mechanisms that modulate its activity. The Na,K-ATPase and the gastric H,K-ATPase are two closely related members of the P-type family of ion transporting ATPases. Despite their homology, these pumps are sorted to different domains in polarized epithelial cells and their enzymatic activities are subject to distinct regulatory pathways. The molecular signals responsible for these properties have begun to be elucidated. It appears that a complex array of inter- and intra-molecular interactions govern these proteins' trafficking, distribution and catalytic capacity.
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Banco de datos:
MEDLINE
Asunto principal:
Bombas Iónicas
/
Transporte de Proteínas
Límite:
Animals
/
Humans
Idioma:
En
Año:
2000
Tipo del documento:
Article