A matrix metalloproteinase induction/activation system exists in the human left ventricular myocardium and is upregulated in heart failure.
Circulation
; 102(16): 1944-9, 2000 Oct 17.
Article
en En
| MEDLINE
| ID: mdl-11034943
ABSTRACT
BACKGROUND:
Matrix metalloproteinases (MMPs) contribute to matrix remodeling in disease states such as tumor metastases. Extracellular matrix metalloproteinase inducer (EMMPRIN) has been reported to increase MMP expression, and membrane-type MMP or MT1-MMP has been implicated to activate MMPs. The present study examined whether and to what degree EMMPRIN and MT1-MMP were expressed in human left ventricular (LV) myocardium as well as the association with MMP activity and expression in dilated cardiomyopathy (DCM). METHODS ANDRESULTS:
LV myocardial zymographic MMP activity increased by >2-fold with both nonischemic DCM (n=21) and ischemic DCM (n=16) compared with normal (n=13). LV myocardial abundance of MMP-9 was increased with both forms of DCM. MMP-2 and MMP-3 were increased with nonischemic DCM. MMP-1 levels were decreased with both forms of DCM. EMMPRIN increased by >250% and MT1-MMP increased by >1000% with both forms of DCM.CONCLUSIONS:
Increased LV myocardial MMP activity and selective upregulation of MMPs with nonischemic and ischemic forms of DCM occurred. Moreover, a local MMP induction/activation system was identified in isolated normal human LV myocytes that was upregulated with DCM. The control of MMP activation and expression in the failing human LV myocardium represents a new and potentially significant therapeutic target for this disease process.
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Banco de datos:
MEDLINE
Asunto principal:
Cardiomiopatía Dilatada
/
Antígenos CD
/
Regulación hacia Arriba
/
Metaloproteinasas de la Matriz
/
Ventrículos Cardíacos
/
Miocardio
/
Antígenos de Neoplasias
Límite:
Adolescent
/
Adult
/
Humans
/
Middle aged
Idioma:
En
Año:
2000
Tipo del documento:
Article