NO synthesis inhibition decreases cortical ACh release and impairs retention of a conditioned response.
Brain Res
; 894(1): 141-4, 2001 Mar 09.
Article
en En
| MEDLINE
| ID: mdl-11245824
ABSTRACT
We investigated in rats the effect N(G)-nitro-L-arginine methyl ester (L-NAME) on retention of a passive avoidance response, and cortical ACh release monitored using the microdialysis technique. Post-training administration of L-NAME impaired 24 h retention of a passive avoidance and decreased cortical ACh release. Both effects of L-NAME were reversed by L-Arg. These results suggest that nitric oxide is involved in retention of the passive avoidance response through the modulation of the forebrain cholinergic system.
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Banco de datos:
MEDLINE
Asunto principal:
Arginina
/
Retención en Psicología
/
Reacción de Prevención
/
Acetilcolina
/
NG-Nitroarginina Metil Éster
/
Inhibidores Enzimáticos
Límite:
Animals
Idioma:
En
Año:
2001
Tipo del documento:
Article