Increased levels of plasma thrombomodulin in patients with acute myocardial infarction who had thrombolytic therapy and achieved successful reperfusion.
Clin Cardiol
; 24(5): 377-9, 2001 May.
Article
en En
| MEDLINE
| ID: mdl-11346245
ABSTRACT
BACKGROUND:
There is a growing body of evidence from animal and in vitro studies for the existence of reperfusion injury after thrombolytic therapy for acute myocardial infarction (AMI), but the patient data are limited.HYPOTHESIS:
We aimed to examine the plasma thrombomodulin (TM) levels as a marker of endothelial injury and to investigate the effect of successful reperfusion on these levels.METHODS:
The study included 32 patients who had a first episode of acute myocardial infarction (AMI) and received intravenous streptokinase therapy.RESULTS:
Thrombomodulin levels increased significantly at 60 min after thrombolysis compared with the levels before thrombolytic therapy (0 min) in 21 (66%) patients who had successful reperfusion (49.09 +/- 10.51 vs. 25.76 +/- 5.55 ng/ml, p < 0.001). There was no difference between the TM levels at 0 and at 60 min of thrombolysis in the remaining 11 (34%) patients who could not achieve reperfusion (27.81 +/- 6.32 vs. 28.72 +/- 7.28 ng/ml, p = 0.35).CONCLUSION:
There was a significant increase in TM levels at 60 min after thrombolysis in a group of patients with AMI who achieved successful reperfusion; this increase may have been caused by the activation/injury of endothelial cells. Data also suggest that the increment in TM levels may be predictive of the potential success of thrombolytic therapy.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Terapia Trombolítica
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Trombomodulina
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Infarto del Miocardio
Tipo de estudio:
Prognostic_studies
Límite:
Aged
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Año:
2001
Tipo del documento:
Article