The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors.
Nat Med
; 7(6): 706-11, 2001 Jun.
Article
en En
| MEDLINE
| ID: mdl-11385508
ABSTRACT
Sonic hedgehog (Shh) is a prototypical morphogen known to regulate epithelial/mesenchymal interactions during embryonic development. We found that the hedgehog-signaling pathway is present in adult cardiovascular tissues and can be activated in vivo. Shh was able to induce robust angiogenesis, characterized by distinct large-diameter vessels. Shh also augmented blood-flow recovery and limb salvage following operatively induced hind-limb ischemia in aged mice. In vitro, Shh had no effect on endothelial-cell migration or proliferation; instead, it induced expression of two families of angiogenic cytokines, including all three vascular endothelial growth factor-1 isoforms and angiopoietins-1 and -2 from interstitial mesenchymal cells. These findings reveal a novel role for Shh as an indirect angiogenic factor regulating expression of multiple angiogenic cytokines and indicate that Shh might have potential therapeutic use for ischemic disorders.
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Banco de datos:
MEDLINE
Asunto principal:
Glicoproteínas de Membrana
/
Transducción de Señal
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Proteínas
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Transactivadores
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Factores de Crecimiento Endotelial
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Linfocinas
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Neovascularización Fisiológica
/
Proteínas de la Membrana
Límite:
Animals
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Female
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Humans
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Male
Idioma:
En
Año:
2001
Tipo del documento:
Article