Liver-derived IGF-I is of importance for normal carbohydrate and lipid metabolism.
Diabetes
; 50(7): 1539-45, 2001 Jul.
Article
en En
| MEDLINE
| ID: mdl-11423474
ABSTRACT
IGF-I is important for postnatal body growth and exhibits insulin-like effects on carbohydrate metabolism. The function of liver-derived IGF-I is still not established, although we previously demonstrated that liver-derived IGF-I is not required for postnatal body growth. Mice whose IGF-I gene in the liver was inactivated at 24 days of age were used to investigate the long-term role of liver-derived IGF-I for carbohydrate and lipid metabolism. Serum levels of leptin in these mice were increased by >100% at 3 months of age, whereas the fat mass of the mice was decreased by 25% at 13 months of age. The mice became markedly hyperinsulinemic and yet normoglycemic, indicating an adequately compensated insulin resistance. Furthermore, they had increased serum levels of cholesterol. We conclude that liver-derived IGF-I is of importance for carbohydrate and lipid metabolism.
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Banco de datos:
MEDLINE
Asunto principal:
Factor I del Crecimiento Similar a la Insulina
/
Carbohidratos de la Dieta
/
Grasas de la Dieta
/
Metabolismo de los Lípidos
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Hígado
Límite:
Animals
Idioma:
En
Año:
2001
Tipo del documento:
Article