Fluorescence resonance energy transfer analysis of CCR-V64I and SDF1-3'a polymorphisms: prevalence in southern Spain hiv type 1+ cohort and noninfected population.
AIDS Res Hum Retroviruses
; 17(8): 663-6, 2001 May 20.
Article
en En
| MEDLINE
| ID: mdl-11429106
ABSTRACT
The relationship between host genotype and AIDS, as well as the different genotype frequencies observed in different populations, have become important topics in HIV research. Therefore, the development of methods that provide faster and reliable results may contribute to further development and knowledge of those topics. We present the results of genotyping SDF1-3'A and CCR2-V64I in 440 HIV-1-infected people and 100 noninfected controls from southern Spain, using a novel method based on real-time PCR with LightCycler technology and fluorescence resonance energy transfer. Frequencies obtained were 23.8% for SDF1-3'A and 9.5% for CCR2-V64I for both HIV+ cohort and general population. Both polymorphisms are in accordance with the Hardy-Weinberg equilibrium law and no differences between patients and controls have been observed.
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Banco de datos:
MEDLINE
Asunto principal:
Infecciones por VIH
/
VIH-1
/
Receptores de Quimiocina
/
Quimiocinas CXC
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Humans
País como asunto:
Europa
Idioma:
En
Año:
2001
Tipo del documento:
Article