Vasoactive intestinal peptide protects guinea-pig detrusor nerves from anoxia/glucopenia injury.
Eur J Pharmacol
; 423(2-3): 229-33, 2001 Jul 06.
Article
en En
| MEDLINE
| ID: mdl-11448489
ABSTRACT
Vasoactive intestinal peptide (VIP) was tested for its capability to protect the intrinsic nerves of guinea-pig urinary bladder from damage due to anoxia/glucopenia and reperfusion. Guinea-pig detrusor strips were mounted for tension recording in small organ baths and the nerves were subjected to electric field stimulation. VIP (0.3 microM) improved significantly the response of strips to electrical field stimulation either during anoxia/glucopenia or thereafter during reperfusion, as compared to untreated tissues. The antioxidant activity of VIP assessed as its capability to scavenge peroxyl radicals during linoleic acid oxidation corresponded to 6.42+/-0.13 pIC(50) M, i.e. close to the concentration proved to protect strips against the anoxic--glucopenic and reperfusion damage.
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Banco de datos:
MEDLINE
Asunto principal:
Vejiga Urinaria
/
Péptido Intestinal Vasoactivo
/
Glucosa
/
Hipoxia
Límite:
Animals
Idioma:
En
Año:
2001
Tipo del documento:
Article