Maternal serum activin A and inhibin A in trisomy 18 pregnancies at 10-14 weeks.
Prenat Diagn
; 21(7): 571-4, 2001 Jul.
Article
en En
| MEDLINE
| ID: mdl-11494294
ABSTRACT
In 45 cases of trisomy 18 and 493 control pregnancies at 10-14 weeks of gestation, maternal serum inhibin A, total activin A, free beta-hCG and PAPP-A were measured. In the trisomy 18 pregnancies the median values were 0.74 MoM for inhibin A, 1.23 MoM for activin A, 0.38 MoM for free beta-hCG and 0.16 MoM for PAPP-A. The degree of deviation from normal in the levels of inhibin and activin is small in comparison with free beta-hCG and PAPP-A and they are therefore unlikely to be of value in improving the sensitivity of 90% for a 1% false-positive rate achieved by screening with fetal nuchal translucency and maternal serum free beta-hCG and PAPP-A.
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Banco de datos:
MEDLINE
Asunto principal:
Diagnóstico Prenatal
/
Trisomía
/
Cromosomas Humanos Par 18
/
Inhibinas
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Año:
2001
Tipo del documento:
Article