CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease.
Trends Genet
; 17(9): 520-7, 2001 Sep.
Article
en En
| MEDLINE
| ID: mdl-11525835
ABSTRACT
CTCF is an evolutionarily conserved zinc finger (ZF) phosphoprotein that binds through combinatorial use of its 11 ZFs to approximately 50 bp target sites that have remarkable sequence variation. Formation of different CTCF-DNA complexes, some of which are methylation-sensitive, results in distinct functions, including gene activation, repression, silencing and chromatin insulation. Disrupting the spectrum of target specificities by ZF mutations or by abnormal selective methylation of targets is associated with cancer. CTCF emerges, therefore, as a central player in networks linking expression domains with epigenetics and cell growth regulation.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Represoras
/
Factores de Transcripción
/
Dedos de Zinc
/
Proteínas de Unión al ADN
Límite:
Animals
/
Humans
Idioma:
En
Año:
2001
Tipo del documento:
Article