Sulfide-mediated dehydrative glycosylation.
J Am Chem Soc
; 123(36): 8766-72, 2001 Sep 12.
Article
en En
| MEDLINE
| ID: mdl-11535081
The development of a new method for glycosylation with 1-hydroxy glycosyl donors employing dialkyl sulfonium reagents is described. The process employs the reagent combination of a dialkyl sulfide and triflic anhydride to effect anomeric bond constructions. This controlled dehydrative coupling of various C(1)-hemiacetal glycosyl donors and nucleophilic acceptors proceeds by way of a sulfide-to-sulfoxide oxidation process in which triflic anhydride serves as the oxidant.
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Banco de datos:
MEDLINE
Asunto principal:
Safrol
/
Sulfuros
Idioma:
En
Año:
2001
Tipo del documento:
Article