Synthesis and biological data of 4-amino-1-(2-chloro-2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl esters, a new series of A1-adenosine receptor (A1AR) ligands.
Bioorg Med Chem Lett
; 11(18): 2529-31, 2001 Sep 17.
Article
en En
| MEDLINE
| ID: mdl-11549462
ABSTRACT
The synthesis of a new family of A1-adenosine receptor (A1AR) ligands 3a-n has been performed in a straightforward way. Affinity data at A1AR, A2AAR and A3AR in bovine membranes show that these new compounds bind the A1AR in a selective way over A2AAR and A3AR and one of them (3j) presents a very high affinity, probably due to the phenethylamine substituent at C-4.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Pirazoles
/
Piridinas
/
Receptores Purinérgicos P1
Límite:
Animals
Idioma:
En
Año:
2001
Tipo del documento:
Article