Failure of a novel balloon-expandable gamma-emitting ((103)Pd) stent to prevent edge effects.
Circulation
; 104(19): 2358-62, 2001 Nov 06.
Article
en En
| MEDLINE
| ID: mdl-11696478
ABSTRACT
BACKGROUND:
Balloon-expandable beta-particle-emitting ((32)P) stents inhibit within-stent neointimal hyperplasia but induce lumen narrowing beyond the stent margins, ie, the so-called "edge effects." METHODS ANDRESULTS:
We prospectively investigated the performance of novel stents impregnated with the gamma-emitting isotope (103)Pd, designed to reduce edge effects, in 24 rabbits. The stents had a length of 18 mm and were mounted on 20-mm-long delivery balloons for deployment. Angiograms were obtained immediately and 1 month after direct implantation of control and 1-, 2-, and 4-mCi (103)Pd stents into the iliac arteries without predilatation or postdilatation. Late lumen loss was measured with quantitative angiography. Neointimal hyperplasia and vascular remodeling were evaluated by histomorphometry. Late lumen loss was inhibited within (103)Pd stents (control 0.18 mm, 1 mCi 0.08 mm, 2 mCi 0.05 mm, and 4 mCi -0.03 mm, P<0.05 all activities versus control). Conversely, late lumen loss occurred at the edges of (103)Pd stents, correlating with areas of high balloon/artery ratios and vessel overstretch injury. Edge effects were primarily due to neointimal hyperplasia but were also caused by negative vessel remodeling at high stent activities.CONCLUSIONS:
Edge effects after implantation of radioisotope stents can occur independently of the isotope chosen for stent impregnation.
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Banco de datos:
MEDLINE
Asunto principal:
Paladio
/
Radioisótopos
/
Stents
/
Implantes Experimentales
/
Oclusión de Injerto Vascular
Tipo de estudio:
Evaluation_studies
/
Observational_studies
Límite:
Animals
Idioma:
En
Año:
2001
Tipo del documento:
Article