Macharistol, a new cytotoxic cinnamylphenol from the stems of Machaerium aristulatum.
J Nat Prod
; 64(11): 1483-5, 2001 Nov.
Article
en En
| MEDLINE
| ID: mdl-11720542
ABSTRACT
A new cinnamylphenol, macharistol (1), along with a known pterocarpan, (+)-medicarpin (2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain (3), and a known isoflavone, formononetin (4), were identified as inactive constituents. Compound 1 was evaluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest dose (25 mg/kg body weight) tested.
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Banco de datos:
MEDLINE
Asunto principal:
Fenoles
/
Pterocarpanos
/
Fabaceae
/
Antineoplásicos Fitogénicos
Límite:
Humans
Idioma:
En
Año:
2001
Tipo del documento:
Article