CD30L up-regulates CD30 and IL-4 expression by T cells.
FEBS Lett
; 508(3): 418-22, 2001 Nov 23.
Article
en En
| MEDLINE
| ID: mdl-11728464
ABSTRACT
CD30L is frequently expressed on acute myeloid leukemia (AML) blasts. Its presence is associated with the co-expression of interleukin-4 (IL-4) receptor and with the expansion of specific T-helper 2 (Th2) cell subsets producing IL-4 and expressing CD30. Recombinant CD30L-bearing cells up-regulated the expression of surface CD30 and increased the production of IL-4 and soluble (s) CD30 by co-cultured T cells. These findings were confirmed with AML blasts expressing surface CD30L, where blocking anti-CD30 antibodies completely abolished the release of sCD30 and reduced the production of IL-4. Our data indicates a direct role of CD30L(+) neoplastic cells in driving the immune response toward a Th2-polarized non-protective state.
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Banco de datos:
MEDLINE
Asunto principal:
Glicoproteínas de Membrana
/
Linfocitos T
/
Interleucina-4
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Antígeno Ki-1
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Células Th2
Límite:
Animals
/
Humans
Idioma:
En
Año:
2001
Tipo del documento:
Article