APC, signal transduction and genetic instability in colorectal cancer.
Nat Rev Cancer
; 1(1): 55-67, 2001 Oct.
Article
en En
| MEDLINE
| ID: mdl-11900252
ABSTRACT
Colorectal cancer arises through a gradual series of histological changes, each of which is accompanied by a specific genetic alteration. In general, an intestinal cell needs to comply with two essential requirements to develop into a cancer it must acquire selective advantage to allow for the initial clonal expansion, and genetic instability to allow for multiple hits in other genes that are responsible for tumour progression and malignant transformation. Inactivation of APC--the gene responsible for most cases of colorectal cancer--might fulfil both requirements.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Colorrectales
/
Transducción de Señal
/
Transactivadores
/
Aberraciones Cromosómicas
/
Genes APC
/
Repeticiones de Microsatélite
Límite:
Animals
/
Humans
Idioma:
En
Año:
2001
Tipo del documento:
Article