[Significance of nitric oxide function in development of cardiac hypertrophy under condition of experimental renal hypertension]. / Znachenie oksida azota v razvitii gipertrofii serdtsa v usloviiakh éksperimental'noi pochechnoi gipertenzii.

ABSTRACT

The development of cardiac hypertrophy was studied under condition of experimental renal hypertension on the rat. The number of cardiac nitric oxide synthase (NOS)-positive neurones increased simultaneously with the increase in NOS-activity in these neurones. A connection was found between the development of cardiac hypertrophy and the activity of NOS in cardiomiocytes. The involvement of NO in the development cardiac hypertrophy as auto- and paracrine regulator is supposed.