Tau gene mutations: dissecting the pathogenesis of FTDP-17.
Trends Mol Med
; 8(12): 555-62, 2002 Dec.
Article
en En
| MEDLINE
| ID: mdl-12470988
ABSTRACT
Tau is a microtubule-associated protein involved in microtubule assembly and stabilization. Abnormal filamentous tau deposits constitute a major defining characteristic of several neurodegenerative diseases, including Alzheimer's disease. Although the presence of tau pathology correlates with the symptoms of Alzheimer's disease, there was no genetic evidence linking tau to neurodegeneration until recently. However, since 1998, the identification of more than 25 mutations in the tau gene, associated with frontotemporal dementia and parkinsonism linked to chromosome 17, has demonstrated that tau dysfunction can lead to neurodegeneration and the development of clinical symptoms.
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Banco de datos:
MEDLINE
Asunto principal:
Proteínas tau
/
Enfermedades Neurodegenerativas
/
Proteínas Asociadas a Microtúbulos
/
Mutación
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Año:
2002
Tipo del documento:
Article