Mutation of linotte causes behavioral defects independently of pigeon in Drosophila.
Neuroreport
; 13(17): 2309-12, 2002 Dec 03.
Article
en En
| MEDLINE
| ID: mdl-12488817
ABSTRACT
The Drosophila linotte1 mutation was isolated from a genetic screen designed to identify learning and memory genes. For some authors, this mutation affects a novel gene specifically involved in adult learning and memory, whereas for others, it is an allele of the derailed receptor tyrosine kinase gene (the linotte/derailed gene) involved in nervous system development. Here, we show that the original derailed mutation induces a memory phenotype. We also report that a new null mutation, lioexc21, affecting specifically the linotte/derailed gene causes behavioral defects, which can be partially rescued by expression of a lio+/drl+ transgene. The data presented here suggest that the memory phenotype of linotte and derailed mutants is a consequence of abnormal brain development due to loss of function of the linotte/derailed encoded receptor tyrosine kinase.
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Banco de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Proteínas Tirosina Quinasas Receptoras
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Proteínas de Drosophila
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Drosophila melanogaster
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Memoria
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Trastornos de la Memoria
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Malformaciones del Sistema Nervioso
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Año:
2002
Tipo del documento:
Article