The Na/Ca-K exchanger gene family.
Ann N Y Acad Sci
; 976: 41-52, 2002 Nov.
Article
en En
| MEDLINE
| ID: mdl-12502532
ABSTRACT
Ca(2+) extrusion driven by both the inward Na(+) gradient as well as the outward K(+) gradient is essential for visual transduction in retinal rod and cone photoreceptors because it removes Ca(2+) that enters photoreceptors via the cGMP-gated and light-sensitive channels. We have cloned rod and cone Na/Ca-K exchanger (NCKX) cDNAs from several species, and we have cloned NCKX cDNAs from lower organisms that lack vertebrate-type vision. Although in situ NCKX physiology has only been documented for vertebrate photoreceptors, it is now clear that NCKX gene products have a much broader distribution pattern. Here, we review some of the structural and functional features that have emerged from our studies on different members of the NCKX gene family.
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Banco de datos:
MEDLINE
Asunto principal:
Enfermedades de la Retina
/
Células Fotorreceptoras Retinianas Bastones
/
Intercambiador de Sodio-Calcio
Límite:
Animals
/
Humans
Idioma:
En
Año:
2002
Tipo del documento:
Article