Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.

Zhuang, Linghang; Wai, John S; Embrey, Mark W; Fisher, Thorsten E; Egbertson, Melissa S; Payne, Linda S; Guare, James P; Vacca, Joseph P; Hazuda, Daria J; Felock, Peter J; Wolfe, Abigail L; Stillmock, Kara A; Witmer, Marc V; Moyer, Gregory; Schleif, William A; Gabryelski, Lori J; Leonard, Yvonne M; Lynch, Joseph J; Michelson, Stuart R; Young, Steven D

Zhuang, Linghang; Wai, John S; Embrey, Mark W; Fisher, Thorsten E; Egbertson, Melissa S; Payne, Linda S; Guare, James P; Vacca, Joseph P; Hazuda, Daria J; Felock, Peter J; Wolfe, Abigail L; Stillmock, Kara A; Witmer, Marc V; Moyer, Gregory; Schleif, William A; Gabryelski, Lori J; Leonard, Yvonne M; Lynch, Joseph J; Michelson, Stuart R; Young, Steven D.

Zhuang L; Departments of Medicinal Chemistry, Antiviral Research, and Pharmacology, Merck Research Laboratories, West Point, Pennsylvania 19486, USA. linghang_zhuang@merck.com

J Med Chem ; 46(4): 453-6, 2003 Feb 13.

Article en En | MEDLINE | ID: mdl-12570367

Asunto(s)

Fármacos Anti-VIH/síntesis química; Inhibidores de Integrasa VIH/síntesis química; VIH-1/efectos de los fármacos; Naftiridinas/síntesis química; Administración Oral; Animales; Fármacos Anti-VIH/química; Fármacos Anti-VIH/farmacología; Línea Celular; Inhibidores de Integrasa VIH/química; Inhibidores de Integrasa VIH/farmacología; Humanos; Inyecciones Intravenosas; Naftiridinas/química; Naftiridinas/farmacología; Ratas; Relación Estructura-Actividad

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Banco de datos: MEDLINE Asunto principal: VIH-1 / Inhibidores de Integrasa VIH / Fármacos Anti-VIH / Naftiridinas Límite: Animals / Humans Idioma: En Año: 2003 Tipo del documento: Article

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