Development of the monosynaptic stretch reflex circuit.
Curr Opin Neurobiol
; 13(1): 96-102, 2003 Feb.
Article
en En
| MEDLINE
| ID: mdl-12593987
ABSTRACT
Significant advances have been made during the past few years in our understanding of how the spinal monosynaptic reflex develops. Transcription factors in the Neurogenin, Runt, ETS, and LIM families control sequential steps of the specification of various subtypes of dorsal root ganglia sensory neurons. The initiation of muscle spindle differentiation requires neuregulin 1, derived from Ia afferent sensory neurons, and signaling through ErbB receptors in intrafusal muscle fibers. Several retrograde signals from the periphery are important for the establishment of late connectivity in the reflex circuit. Finally, neurotrophin 3 released from muscle spindles regulates the strength of sensory-motor connections within the spinal cord postnatally.
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Banco de datos:
MEDLINE
Asunto principal:
Reflejo Monosináptico
/
Vías Aferentes
/
Husos Musculares
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Músculo Esquelético
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Vías Eferentes
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Ganglios Espinales
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Células del Asta Anterior
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Neuronas Aferentes
Límite:
Animals
/
Humans
Idioma:
En
Año:
2003
Tipo del documento:
Article