Interleukin 6 concentration in ascitic fluid of cirrhotic patients: relationship with previous episodes of spontaneous bacterial peritonitis.
J Gastroenterol
; 38(2): 149-52, 2003.
Article
en En
| MEDLINE
| ID: mdl-12640528
ABSTRACT
BACKGROUND:
We aimed to determine whether inter-leukin (IL)-6 concentrations in plasma and ascitic fluid from cirrhotic patients with previous episodes of spontaneous bacterial peritonitis (SBP) differred from those with no previous episodes of SBP.METHODS:
Cirrhotic patients with ascites were divided into two groups G1, without previous episodes of SBP (n = 6), and G2, with previous episodes of SBP (n = 6). Patients with chronic heart failure (n = 5) with ascites, without hepatic diseases, were included as controls (G3). IL-6 concentration was determined in ascitic fluid and plasma by enzyme-linked immunosorbent assay (ELISA). A group of healthy subjects (n = 8) was used as a control for the blood IL-6 assay.RESULTS:
IL-6 concentration in ascitic fluid was significantly higher in G1 (P < 0.05) than in G2 or G3. No significant difference in plasma IL-6 concentrations was observed between the groups or between each group and the healthy subjects. A significant positive linear correlation (P < 0.002) was observed between IL-6 concentration and total protein in ascitic fluid.CONCLUSIONS:
A low concentration of IL-6 in ascitic fluid could predispose cirrhotic patients to SBP.
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Banco de datos:
MEDLINE
Asunto principal:
Peritonitis
/
Infecciones Bacterianas
/
Líquido Ascítico
/
Interleucina-6
/
Cirrosis Hepática
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
2003
Tipo del documento:
Article