Design and synthesis of naphthalenic dimers as selective MT1 melatoninergic ligands.
J Med Chem
; 46(7): 1127-9, 2003 Mar 27.
Article
en En
| MEDLINE
| ID: mdl-12646022
ABSTRACT
We report the synthesis and binding properties at MT(1) and MT(2) receptors of the first example of agomelatine (N-[2-(7-methoxynaphth-1-yl)ethyl]acetamide) dimers in which two agomelatine moieties are linked together through their methoxy substituent by a polymethylene side chain according to the "bivalent ligand" approach. Some of these compounds behave as MT(1)-selective ligands. The most selective one (5) behaves as an antagonist.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Receptores Citoplasmáticos y Nucleares
/
Receptores de Superficie Celular
/
Acetamidas
/
Melatonina
/
Naftalenos
Límite:
Animals
/
Humans
Idioma:
En
Año:
2003
Tipo del documento:
Article