Retroinverso analogue of the antiviral octapeptide C8 inhibits feline immunodeficiency virus in serum.
J Med Chem
; 46(10): 1807-10, 2003 May 08.
Article
en En
| MEDLINE
| ID: mdl-12723944
ABSTRACT
We described the antiviral activity of an octapeptide corresponding to a Trp-rich domain of feline immunodeficiency virus (FIV) transmembrane glycoprotein. To overcome the limited enzymatic stability of short peptides, the retroinverso analogue was prepared and tested for inhibitory activity of FIV in the presence or absence of normal cat serum. Differently from the unmodified peptide, the retroinverso analogue maintains strong inhibitory activity in serum. NMR studies showed that it displays crucial conformational features believed to be important for antiviral activity.
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Banco de datos:
MEDLINE
Asunto principal:
Antivirales
/
Oligopéptidos
/
Glicoproteínas de Membrana
/
Proteínas de los Retroviridae
/
Virus de la Inmunodeficiencia Felina
Límite:
Animals
Idioma:
En
Año:
2003
Tipo del documento:
Article