Anti-AIDS agents 54. A potent anti-HIV chalcone and flavonoids from genus Desmos.
Bioorg Med Chem Lett
; 13(10): 1813-5, 2003 May 19.
Article
en En
| MEDLINE
| ID: mdl-12729671
ABSTRACT
Sixteen flavonoids and their derivatives isolated from Desmos spp. were evaluated for inhibition of HIV replication in H9 lymphocyte cells. 2-Methoxy-3-methyl-4,6-dihydroxy-5-(3'-hydroxy)cinnamoylbenzaldehyde (12) and lawinal (6) demonstrated potent anti-HIV activity with EC(50) values of 0.022 and 2.30 microg/mL and therapeutic indexes of 489 and 45.2, respectively. Compound 12 appears to be an excellent lead for further anti-HIV drug development.
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Banco de datos:
MEDLINE
Asunto principal:
Flavonoides
/
Chalcona
/
Fármacos Anti-VIH
/
Annonaceae
Límite:
Humans
Idioma:
En
Año:
2003
Tipo del documento:
Article