[Therapeutic drug monitoring of mycophenolate mofetil, sirolimus and cyclosporine at C2]. / Suivi thérapeutique pharmacologique de l'acide mycophénolique, du sirolimus et de la cilosporine au moyen du C2.

The evolutions in treatments and clinical practices in organ transplantations led to modifications in the therapeutic drug monitoring (TDM) of immunosuppressive drugs. A focus is made regarding the C2 sampling of cyclosporin, as well as the TDM of mycophenolate mofetil and sirolimus. A review of literature about the evolution of drug monitoring, technical methods and sampling strategies is described. Arguments in favour of TDM are thus a decrease in the frequency of both graft rejection and adverse drug reactions, however, new strategies or new targets are needed in new associations or indications.