Structures of immunophilins and their ligand complexes.
Curr Top Med Chem
; 3(12): 1392-409, 2003.
Article
en En
| MEDLINE
| ID: mdl-12871171
ABSTRACT
This review includes an analysis of available X-ray and NMR structures of both members of the immunophilin family; cyclophilins and the FK-506 binding proteins (FKBPs). Available structures are compared and contrasted to highlight different structural features seen both within and between species. Each immunophilin family has been structurally characterised with a variety of small molecule ligands, principally immunosuppressive drugs and their analogues and an overview of these complexes is also presented. Currently the Protein Data Base contains over 60 entries for cyclophilins and over 40 entries for FKBPs. A number of FKBP related structures are also available including structures of MIP (Macrophage Infectivity Potentiator protein) from Legionella pneumophila and Trypanosoma cruzi and Trigger Factor from Mycoplasma genitalium. For all structures discussed in the review a summary of the available biological data is also presented.
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Banco de datos:
MEDLINE
Asunto principal:
Unión Proteica
/
Inmunofilinas
Límite:
Animals
/
Humans
Idioma:
En
Año:
2003
Tipo del documento:
Article