Viral diarrhoea in young children in two districts in Nigeria.
Cent Afr J Med
; 48(5-6): 59-63, 2002.
Article
en En
| MEDLINE
| ID: mdl-12971160
ABSTRACT
OBJECTIVES:
To determine the prevalence of viral agents of diarrhoea in Ilorin and Lagos, two zones in Nigeria.DESIGN:
A survey of young children who had clinically confirmed diarrhoea.SETTING:
University of Ilorin Teaching Hospital in Ilorin, Kware State and the Massey Street Children's Hospital in Lagos State, Nigeria.SUBJECTS:
108 children under the age of five.RESULTS:
The prevalence rates observed were 33.3% for rotavirus, 6.7% for adenovirus and 1.2% for astrovirus. The rotavirus strains were characterized further. PAGE determined the presence of seven patterns of RNA electropherotypes, with one short RN patterns and six long patterns. The G and P types of selected rotavirus positive samples were characterized by RT-PCR techniques. The VP7 G typing showed that GI was the most prevalent single strain found (8.3%), while G3 and G4 accounted for 6.7% and 1.7%. The rate of mixed G serotypes was 26.7%. The P[6] genotype was the most prevalent (52%) and the P[4] had a prevalence of 8%. The mixed P genotype accounted for 28% of the rotavirus strains. The high rate of mixed infection may have an implication on vaccine development.CONCLUSION:
Rotavirus was the most prevalent virus in the study with astrovirus being the second most prevalent. There was only a single incidence of astrovirus.
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Banco de datos:
MEDLINE
Asunto principal:
Infecciones por Rotavirus
/
Rotavirus
/
Diarrea
Tipo de estudio:
Prevalence_studies
/
Risk_factors_studies
Límite:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País como asunto:
Africa
Idioma:
En
Año:
2002
Tipo del documento:
Article