DNA adducts detected by 32P-postlabelling, in the intestine of rats given bile from patients with familial adenomatous polyposis and from unaffected controls.
Carcinogenesis
; 13(4): 731-5, 1992 Apr.
Article
en En
| MEDLINE
| ID: mdl-1315631
ABSTRACT
Duodenal adenomas are common in patients with familial adenomatous polyposis (FAP) and cluster around the papilla, suggesting the involvement of bile in their development. Using 32P-postlabelling we determined levels of DNA adducts in the small bowel and colon of rats treated with bile from FAP and control patients. We found a significantly higher level of adducts in the small bowel of rats treated with FAP gallbladder bile compared with control gallbladder bile (P = 0.0034). This result supports the hypothesis that bile plays a role in the development of neoplasia in the foregut of FAP patients.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Bilis
/
ADN
/
Poliposis Adenomatosa del Colon
/
Intestinos
Límite:
Adolescent
/
Adult
/
Aged
/
Animals
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
1992
Tipo del documento:
Article