[The reactivity of the hypophyseal-adrenal system in rats with different forms of adaptive behavioral pathology]. / Reaktivnost' gipofiz-adrenalovoi sistemy krys pri raznykh formakh patologii adaptivnogo povedeniia.
Zh Vyssh Nerv Deiat Im I P Pavlova
; 42(4): 748-53, 1992.
Article
en Ru
| MEDLINE
| ID: mdl-1332294
ABSTRACT
The dexamethasone suppression test (DST) was applied to male Wistar rats with different models of depression group with the learned helplessness, group with informational neurosis provided by time-deficit conditioned avoidance training, as well as groups of rats of two strains selected for low (KLA)--and high (KHA) avoidance learning. The pre-dexamethasone basal and stress-induced corticosterone levels were similar in intact rats and those exposed to inescapable shock. The dexamethasone administration (5 mkg/kg) failed to decrease the serum corticosterone level in rats with learned helplessness. The informational neurosis increased significantly the basal corticosterone level and decreased the stress response. Serum corticosterone levels were similar in KLA and KHA rats. These results give evidence that two stress-induced rat models of depression with similar behavioural disturbances (reduction of escape/avoidance reactions) exhibit marked differences in the activity of hypothalamo-pituitary-adrenal (HPA) axis.
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Banco de datos:
MEDLINE
Asunto principal:
Sistema Hipófiso-Suprarrenal
/
Conducta Animal
/
Adaptación Psicológica
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
Ru
Año:
1992
Tipo del documento:
Article