Molecular cloning of the interleukin-1 beta converting enzyme.
Science
; 256(5053): 97-100, 1992 Apr 03.
Article
en En
| MEDLINE
| ID: mdl-1373520
ABSTRACT
Interleukin-1 beta (IL-1 beta) mediates a wide range of immune and inflammatory responses. The active cytokine is generated by proteolytic cleavage of an inactive precursor. A complementary DNA encoding a protease that carries out this cleavage has been cloned. Recombinant expression in COS-7 cells enabled the cells to process precursor IL-1 beta to the mature form. Sequence analysis indicated that the enzyme itself may undergo proteolytic processing. The gene encoding the protease was mapped to chromosomal band 11q23, a site frequently involved in rearrangement in human cancers.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Cromosomas Humanos Par 11
/
Metaloendopeptidasas
/
Precursores Enzimáticos
Límite:
Animals
/
Humans
Idioma:
En
Año:
1992
Tipo del documento:
Article