Molecular cloning of substance P receptor cDNA from guinea-pig uterus.
Biochim Biophys Acta
; 1131(1): 99-102, 1992 May 07.
Article
en En
| MEDLINE
| ID: mdl-1374648
ABSTRACT
A cDNA encoding guinea-pig uterine substance P (SP) receptor has been isolated using the homology screening approach. Northern blot analysis reveals that the corresponding mRNA, of approx. 4.8 kb, is expressed in all tissues tested, but predominantly in the uteri of non-pregnant animals; during pregnancy its expression is reduced. The guinea-pig SP receptor was expressed in COS-7 cells and demonstrated relative ligand affinity in the order SP much greater than neurokinin A greater than neurokinin B.
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Banco de datos:
MEDLINE
Asunto principal:
Útero
/
ADN Recombinante
/
Receptores de Neurotransmisores
Límite:
Animals
Idioma:
En
Año:
1992
Tipo del documento:
Article