Targeting oxidative stress-related diseases: organochalcogen catalysts as redox sensitizers.
Biochem Pharmacol
; 66(10): 2021-8, 2003 Nov 15.
Article
en En
| MEDLINE
| ID: mdl-14599560
ABSTRACT
Tumor cells proliferate under conditions of oxidative stress. A novel therapeutic approach would be to enhance the cellular effects of the reactive oxygen species formed under these conditions by supplementation with a redox catalyst. This provides a means to target and specifically destroy cancer cells via oxidation of redox-sensitive proteins, such as transcription factors, while leaving cells with a normal redox balance largely unaffected. We have previously reported a preliminary observation on the effects of pro-oxidant catalysts that enhance cancer cell death. This paper presents a detailed in vitro investigation into the mechanism of action of synthetic glutathione peroxidase mimics on a model Sp1 transcription factor peptide. The structure and redox potential of these mimics correlate with their ability to catalyze the oxidation of this zinc-binding motif by H(2)O(2) and these compounds promise therapeutic potential by promoting H(2)O(2)-induced PC12 cell death.
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Banco de datos:
MEDLINE
Asunto principal:
Calcógenos
/
Estrés Oxidativo
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Año:
2003
Tipo del documento:
Article