[Influence of obesity on pharmacokinetics and pharmacodynamics of isoflurane].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
; 25(5): 615-8, 2003 Oct.
Article
en Zh
| MEDLINE
| ID: mdl-14650171
ABSTRACT
OBJECTIVE:
To observe the effect of obesity on pharmacokinetics and pharmacodynamics of isoflurane.METHODS:
Twenty-six patients undergoing cholecystectomy were divided into obese group (Group A, BMI > or = 27, n = 13) and normal body weight group (Group N, BMI < or = 24, n = 13) according to body mass index (BMI). All patients were given to the same isoflurane anesthesia. Inspired and end-expired concentrations of isoflurane were monitored and uptake fraction of isoflurane were calculated.RESULTS:
Isoflurane concentrations of vaporizer in Group A [(1.8 +/- 0.3)%] were evidently higher than those in Group N [(1.5 +/- 0.1)%] at all observed points (P < 0.05 or P < 0.01). Uptake fraction of isoflurane in Group A were higher than those in Group N at observed points (P < 0.05, P < 0.01 or P < 0.001), but there were no differences in the time when isoflurane concentration was lowered to 50% and awake time between the two groups after discontinuing inhaling isoflurane.CONCLUSIONS:
Obese patients demand higher inspired concentration and uptake of isoflurane than those in normal weight patients but discharge of isoflurane was influenced by obesity within the observed period of (66 +/- 33) min.
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Banco de datos:
MEDLINE
Asunto principal:
Colecistectomía Laparoscópica
/
Anestésicos por Inhalación
/
Isoflurano
/
Obesidad
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Año:
2003
Tipo del documento:
Article