In vivo measurement of leukocyte viscosity during capillary plugging.
J Biomech Eng
; 114(4): 533-8, 1992 Nov.
Article
en En
| MEDLINE
| ID: mdl-1487908
ABSTRACT
Leukocyte plugging of capillaries in vivo was measured in rat spinotrapezius muscle. The plug durations, leukocyte and capillary dimensions, and arteriolar pressure at the plug sites were applied to the mechanical model of Needham and Hochmuth (1990) to estimate the leukocyte viscosities. The viscosity distribution of 389 cells was lognormal with a median value of 232 Poise. 3.1 percent of the cells were apparently activated and displayed viscosities greater than 3000 Poise. The median viscosity suggests that inactivated leukocytes have a minimal effect on blood flow, but that leukocyte activation may result in significant increases in microvascular flow resistance.
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Banco de datos:
MEDLINE
Asunto principal:
Resistencia Vascular
/
Viscosidad Sanguínea
/
Leucocitos
/
Modelos Cardiovasculares
Límite:
Animals
Idioma:
En
Año:
1992
Tipo del documento:
Article