Are sense-antisense peptide interactions between HIV-1 (gp120), CD4, and the proto oncogene product p56lck important?
Med Hypotheses
; 38(4): 322-4, 1992 Aug.
Article
en En
| MEDLINE
| ID: mdl-1491632
ABSTRACT
The finding that codons for hydrophobic and hydrophilic amino acids are generally complemented by codons for hydrophilic and hydrophobic amino acids respectively has led to a novel observation. The antisense peptides coded for by the complementary DNA strand of biologically active peptides are able to bind their active sense counterparts with high specificity. Sense-antisense relationships have been observed in several peptide species as well as in receptor-ligand interactions. The idea that sense-antisense interactions are biologically relevant and indeed feasible among complex molecules prompts the examination of virus-host cell interactions. We propose such a sense-antisense interaction exists between the HIV glycoprotein gp120 and the intracellular domain of the HIV receptor CD4. This interaction is at a site which may be occupied by the proto oncogene product p56lck.
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Banco de datos:
MEDLINE
Asunto principal:
Proteína gp120 de Envoltorio del VIH
/
VIH-1
Límite:
Humans
Idioma:
En
Año:
1992
Tipo del documento:
Article