[Extra-membranous glomerulonephritis: report of a family and new physiopathological concepts]. / Les glomérulonéphrites extra-membraneuses: histoire d'une famille et nouveaux concepts physiopathologiques.
Bull Acad Natl Med
; 187(5): 921-32; discussion 932-4, 2003.
Article
en Fr
| MEDLINE
| ID: mdl-14979057
ABSTRACT
Membranous glomerulonephritis (MGN) is a major cause of the nephrotic syndrome and chronic renal insufficiency. Studies on the reactivity of nephritogenic antibodies implicated in a case of antenatal MGN led to identify for the first time a target of the immune conflict in glomeruli, neutral endopeptidase (CD10). This enzyme that is restricted to certain tissues, being strongly expressed in the placenta and on glomerular podocytes, is involved in the catabolism of a number of regulatory peptides, particularly those involved in vasomotricity. We showed that the nephritogenic antibodies blocked enzymatic activity and that the mother became immunized at the time of a previous pregnancy because she was neutral endopeptidase-deficient. Two additional families have been identified since then. The pathophysiologic mechanisms that we have unraveled are reminiscent of Rhesus immunization and open up new avenues for therapeutic intervention.
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Banco de datos:
MEDLINE
Asunto principal:
Glomerulonefritis Membranosa
/
Neprilisina
/
Inmunidad Materno-Adquirida
/
Isoanticuerpos
/
Isoantígenos
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Newborn
/
Pregnancy
Idioma:
Fr
Año:
2003
Tipo del documento:
Article