Serotoninergic polymorphisms (5-HTTLPR and 5-HT2A): association studies with psychosis in Alzheimer disease.
Genet Test
; 7(4): 309-14, 2003.
Article
en En
| MEDLINE
| ID: mdl-15000807
ABSTRACT
Patients with Alzheimer disease (AD) often exhibit psychotic symptoms associated with cognitive impairment. A few association studies have been carried out to determine if the serotonin transporter and receptor genes are potential risk factors for AD and/or associated psychopathology. The aim of this study was to investigate the association of a serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the 5-HT2A receptor T102C polymorphism with the risk of developing dementia and/or psychotic symptoms in a group of sporadic AD patients from Italy. No significant differences in the distribution of allele and genotype frequencies of 5-HTTLPR and 5-HT2A T102C were found between patient and control groups. However, a significant association between the C102/C102 5-HT2A genotype and psychotic symptoms (p < 0.001) was observed. Our data strongly confirm results from previous studies suggesting that the C102 allele of the 5-HT2A receptor is associated with the occurrence of psychotic symptoms in AD. On the contrary, the serotonin transporter does not appear to be a major susceptibility factor in the pathophysiology of the disease.
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Banco de datos:
MEDLINE
Asunto principal:
Proteínas de Transporte de Membrana
/
Polimorfismo Genético
/
Trastornos Psicóticos
/
Glicoproteínas de Membrana
/
Proteínas Portadoras
/
Receptor de Serotonina 5-HT2A
/
Enfermedad de Alzheimer
/
Proteínas del Tejido Nervioso
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Male
País como asunto:
Europa
Idioma:
En
Año:
2003
Tipo del documento:
Article