Natural polymorphism of cytomegalovirus DNA polymerase lies in two nonconserved regions located between domains delta-C and II and between domains III and I.
Antimicrob Agents Chemother
; 48(5): 1865-8, 2004 May.
Article
en En
| MEDLINE
| ID: mdl-15105145
ABSTRACT
We described the natural polymorphism of cytomegalovirus DNA polymerase in 42 unrelated isolates susceptible to ganciclovir, foscarnet, and cidofovir. All variations, including an eight-amino-acid deletion, were located between domains delta-C and II and between domains III and I, suggesting that these specific residues are not involved in enzymatic functions.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Citomegalovirus
/
ADN Polimerasa Dirigida por ADN
Límite:
Humans
Idioma:
En
Año:
2004
Tipo del documento:
Article