Studies on anti-Helicobacter pylori agents. Part 3: A novel, efficacious cephem derivative, FR193879.
Bioorg Med Chem Lett
; 14(10): 2627-31, 2004 May 17.
Article
en En
| MEDLINE
| ID: mdl-15109666
ABSTRACT
The synthesis, therapeutic efficacy against H. pylori, and preliminary safety of the novel cephem derivative, FR193879 (8a) are described. Compound 8a having a (4-carbamoylmethylthiazol-2-yl)thio moiety at the 3-position and a phenylacetamido at the 7-position was found to have good safety showing a nontoxic dose of > 100 mg/kg in dogs in a 4-week repeat dose toxicity study and extremely potent therapeutic efficacy against H. pylori, showing 30 times superior activity compared to AMPC, and did not display cross-resistance with CAM or MNZ.
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Banco de datos:
MEDLINE
Asunto principal:
Cefalosporinas
/
Helicobacter pylori
/
Antibacterianos
Límite:
Animals
Idioma:
En
Año:
2004
Tipo del documento:
Article