A-71623, a selective CCK-A receptor agonist, suppresses food intake in the mouse, dog, and monkey.
Pharmacol Biochem Behav
; 42(4): 699-704, 1992 Aug.
Article
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| MEDLINE
| ID: mdl-1513850
ABSTRACT
The anorectic actions of cholecystokinin (CCK)-8 and of a selective CCK-A agonist, A-71623, were examined in CD1 mice, beagle dogs, and cynomolgus monkeys. A-71623 suppressed intakes in all species tested, and the effects were blocked by a selective CCK-A antagonist, A-70104. In the dog only, CCK-8 was more potent on a molar basis compared to A-71623, although the effects of both CCK agonists were more short-lived in the dog compared to the other species tested. Our results support other evidence suggesting that the anorectic actions of exogenous application of CCK-8 in these species are mediated via stimulation of the CCK-A receptor subtype.
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Banco de datos:
MEDLINE
Asunto principal:
Tetragastrina
/
Receptores de Colecistoquinina
/
Ingestión de Alimentos
Límite:
Animals
Idioma:
En
Año:
1992
Tipo del documento:
Article