[Muscle diseases in an internal medicine department]. / Diagnostic des maladies musculaires dans un service de médecine interne.

ABSTRACT

PURPOSE: (1) To describe the causes of muscular symptoms in patients undergoing a muscle biopsy in an internal medicine department; (2) to evaluate the diagnostic value of electromyography (EMG), CPK level and muscle biopsy. METHODS: A retrospective study including 90 patients from June 1995 to March 2001. RESULTS: The diagnosis were inflammatory diseases (n = 35), non-organic (n = 24), peripheral neuropathy (n = 8), undetermined organic diseases (n = 7), metabolic diseases (n = 5), toxic diseases (n = 4), infectious diseases (n = 4), amyloidosis (n = 3). Diagnosis value of EMG, CPK and biopsy for organicity were sensibility 82%, 47% and 29%; specificity 46%, 91%, 100%; positive predictive value 78%, 94% and 100%; negative predictive value 50%, 40% and 36%. Muscle biopsy is always normal when CPK and EMG are normal. It allows a diagnosis in one out of three cases if EMG and CPK are differing. It is also indicated when CPK are normal and EMG is myogenic. CONCLUSION: Numerous diseases account for muscular symptoms. The low rate of diagnostic muscle biopsy imposes a comprehensive clinical approach of the patient and justify the implication of internal medicine physicians in his care. Early intervention of a psychosomatic medicine practitioner in the diagnostic procedure should be evaluated to diminish the number of non-contributory biopsies.