Human T cell lymphotropic virus (HTLV) type-1-specific CD8+ T cells: frequency and immunodominance hierarchy.
J Infect Dis
; 189(12): 2294-8, 2004 Jun 15.
Article
en En
| MEDLINE
| ID: mdl-15181578
ABSTRACT
Human T cell lymphotropic virus type 1 (HTLV-1) causes HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). We used interferon- gamma enzyme-linked immunospot assays with overlapping peptides spanning the entire HTLV-1 proteome to test whether the HTLV-1-specific CD8(+) T cells differed significantly in frequency or immunodominance hierarchy between patients with HAM/TSP and asymptomatic carriers and whether the frequency correlated with provirus load. Tax was the immunodominant target antigen. There was no significant qualitative or quantitative difference in the HTLV-1-specific CD8(+) T cell response between the 2 groups. Virus-specific CD8(+) T cell frequency alone does not indicate the effectiveness of the cytotoxic T lymphocyte response in controlling provirus load at equilibrium.
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Banco de datos:
MEDLINE
Asunto principal:
Virus Linfotrópico T Tipo 1 Humano
/
Paraparesia Espástica Tropical
/
Portador Sano
/
Epítopos Inmunodominantes
/
Linfocitos T CD8-positivos
Tipo de estudio:
Qualitative_research
Límite:
Humans
Idioma:
En
Año:
2004
Tipo del documento:
Article