Expression of TRAIL, DR4, and DR5 in kidney and serum from patients receiving renal transplantation.
Transplant Proc
; 36(5): 1340-3, 2004 Jun.
Article
en En
| MEDLINE
| ID: mdl-15251327
ABSTRACT
Renal transplantation is the best treatment of some end-stage renal diseases. Unfortunately, not every transplant is successful due to the rejection or dysfunction of the transplanted kidney. Many cytokines participate in rejection by inducing inflammation or apoptosis. In this study, the expressions of TRAIL, DR4, and DR5 in rejected renal tissue and of serum soluble TRAIL (sTRAIL) in patients with kidney rejection were investigated by immunohistochemical staining and sandwich enzyme-linked immunosorbent assay, respectively. The results showed that the expression of TRAIL, DR4 and DR5, and serum sTRAIL levels were markedly upregulated among renal transplant patients. Since both membrane and soluble forms of TRAIL can induce apoptosis of DR4/DR5-expressing cells via recruiting FADD and caspase 8, elevated TRAIL and its receptors may participate in renal graft rejection.
Search on Google
Banco de datos:
MEDLINE
Asunto principal:
Glicoproteínas de Membrana
/
Antígeno HLA-DR4
/
Antígeno HLA-DR5
/
Trasplante de Riñón
/
Factor de Necrosis Tumoral alfa
Límite:
Humans
Idioma:
En
Año:
2004
Tipo del documento:
Article