Vagus nerve stimulation therapy: 5-year or greater outcome at a university-based epilepsy center.
Seizure
; 13(8): 587-90, 2004 Dec.
Article
en En
| MEDLINE
| ID: mdl-15519919
ABSTRACT
OBJECTIVE:
This retrospective study documented long-term outcome of patients receiving vagus nerve stimulation (VNS) therapy for pharmacoresistant epilepsy.METHODS:
Medical charts of 28 patients implanted for 5 years or longer were reviewed for changes in seizure frequency after 1 year of VNS therapy and at follow up, which ranged from 5 to 7 years. Numbers of antiepileptic drugs (AEDs) taken by the patients were also computed at 1 year and follow up. One patient had died and one had discontinued VNS therapy; data were available for 26 patients.RESULTS:
The median percent change in seizure frequency from baseline increased from -28% (P = 0.0053, Wilcoxon signed-rank test) at 12 months to -72% (P < 0.0001) at follow up. Some patients whose seizure frequency was not reduced during the initial 12 months of VNS therapy did experience reductions in seizure frequency during the follow-up period.CONCLUSION:
In this retrospective study, the effectiveness of VNS therapy increased over time. Physicians should be aware that response to VNS therapy may be delayed for some patients.
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Banco de datos:
MEDLINE
Asunto principal:
Nervio Vago
/
Terapia por Estimulación Eléctrica
/
Epilepsia
/
Atención Ambulatoria
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Año:
2004
Tipo del documento:
Article