Angiotensin converting enzyme insertion/deletion polymorphism and the risk of heart failure in hypertensive subjects.
Eur Heart J
; 25(23): 2143-8, 2004 Dec.
Article
en En
| MEDLINE
| ID: mdl-15571830
ABSTRACT
AIMS:
Cardiac angiotensin-I converting enzyme (ACE) activity is influenced by the ACE I/D polymorphism. Evidence suggests that the DD-genotype may be a risk factor for cardiac hypertrophy and heart failure, especially in hypertensive subjects. We assessed the relation between the ACE I/D polymorphism and the risk of incident heart failure in normotensive and hypertensive subjects. METHODS ANDRESULTS:
We investigated 4264 normotensive and 2174 hypertensive participants of the Rotterdam Study, a population based prospective cohort study. All subjects were available for follow-up from 1990 until 2000. Incidence rates (IR) of heart failure in normotensive subjects were the same over all genotype strata (10 per 1000 person-years). In hypertensive subjects, the IR increased with the number of D-alleles present (II IR=13, ID IR=18 and DD IR=20 per 1000 person-years). Hypertensive subjects carrying the II-genotype did not have an increased risk of heart failure compared to normotensive II subjects. However, hypertensive subjects carrying one or two copies of the D-allele did have a significantly increased risk of heart failure (ID RR 1.4 (1.1-1.9) and DD RR 1.5 (1.2-2.1)).CONCLUSION:
Our findings suggest that the ACE I/D polymorphism may play a modifying role in the development of heart failure in hypertensive subjects.
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Banco de datos:
MEDLINE
Asunto principal:
Peptidil-Dipeptidasa A
/
Insuficiencia Cardíaca
/
Hipertensión
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
2004
Tipo del documento:
Article