Design, synthesis, and biological evaluation of prazosin-related derivatives as multipotent compounds.
J Med Chem
; 48(1): 28-31, 2005 Jan 13.
Article
en En
| MEDLINE
| ID: mdl-15633998
ABSTRACT
To combine in the same molecule alpha(1)-adrenoreceptor blocking and antioxidant properties, compounds 2-5 were designed and synthesized. All compounds were effective alpha(1)-adrenoreceptor antagonists and were tested in both functional and binding assays. In addition, compounds 2 and 5 also displayed significant capacity to inhibit intracellular oxidative stress, whereas 3-5 exerted potent antiproliferative activity in lymph node carcinoma of prostate cells.
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Banco de datos:
MEDLINE
Asunto principal:
Prazosina
/
Antagonistas Adrenérgicos alfa
/
Antioxidantes
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Año:
2005
Tipo del documento:
Article